An Old retired Bull told me he carries three guns as a result of his decreasing mobility. His adage was the best gunfight he was in was the one he wasn't there for. Unfortunately as age creeps up on him, his ambulation has suffered. Ergo his options have declined as well. I imagine a person in a wheelchair really has no options except to fight. If they could strap a directional mine or a couple of bouncing betty's to their chair , I'd imagine they would.
Certainly as you take away the option of retreat or flight, the consequences you face become more dire. Location, timing, weather, health and who is with you all enter into the equation. I used to strap on when I dated this one girl who definitely was not a gunny. She asked me why I always carried a weapon. I told her I didn't always but I always carried when I was with her. I got a raised eyebrow with that. I told her if I was by myself I could always run like hell. With her present the flight option was removed. She kinda got that.
Remember, You don't have to outrun the bear, You just have to outrun the slowest one there.